Federica Sotgia Selected Research

Lactic Acid (Lactate)

1/2017	Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer.
4/2014	Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth.
9/2013	Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery.
8/2013	Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4.
5/2013	Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer.
5/2013	Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.
3/2013	Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment.
9/2012	Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth.
9/2012	Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
8/2012	Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Federica Sotgia Research Topics

Disease

129	Neoplasms (Cancer) 01/2021 - 06/2003
77	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2006
42	Neoplasm Metastasis (Metastasis) 01/2021 - 08/2007
14	Carcinogenesis 10/2017 - 06/2003
13	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 04/2010
12	Hypoxia (Hypoxemia) 01/2020 - 04/2010
10	Inflammation (Inflammations) 10/2015 - 04/2010
5	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2020 - 04/2009
5	Melanoma (Melanoma, Malignant) 01/2018 - 10/2010
5	Starvation 11/2012 - 08/2011
5	Lymphatic Metastasis 04/2012 - 08/2010
5	Muscular Dystrophies (Muscular Dystrophy) 04/2010 - 01/2002
4	Ovarian Neoplasms (Ovarian Cancer) 09/2017 - 01/2012
4	Prostatic Neoplasms (Prostate Cancer) 08/2009 - 08/2007
3	Infections 03/2020 - 03/2015
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018 - 11/2011
3	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 05/2013
3	Communicable Diseases (Infectious Diseases) 09/2017 - 08/2013
3	5 Hypomyelinating Leukodystrophy 01/2012 - 10/2006
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 04/2010 - 10/2003
3	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 02/2010 - 01/2002
3	Hyperplasia 11/2006 - 06/2003
2	Disease Progression 01/2021 - 08/2009
2	COVID-19 10/2020 - 03/2020
2	Carcinoma (Carcinomatosis) 01/2017 - 04/2014
2	Tics (Tic) 06/2015 - 03/2015
2	Hypertrophy 05/2013 - 06/2012

Drug/Important Bio-Agent (IBA)

44	Caveolin 1IBA 01/2021 - 06/2003
32	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2003
31	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2009
30	Lactic Acid (Lactate)FDA LinkGeneric 01/2017 - 06/2010
21	AntioxidantsIBA 01/2021 - 09/2010
20	KetonesIBA 09/2013 - 09/2010
16	Pharmaceutical PreparationsIBA 01/2021 - 06/2009
16	Tamoxifen FDA LinkGeneric 01/2020 - 08/2008
14	Adenosine Triphosphate (ATP)IBA 01/2021 - 12/2009
12	EnzymesIBA 12/2017 - 02/2011
11	Doxycycline (Periostat)FDA LinkGeneric 03/2020 - 01/2015
10	Glutamine (L-Glutamine)FDA Link 04/2014 - 09/2010
10	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2012 - 08/2011
8	Estrogens (Estrogen)FDA Link 01/2020 - 11/2006
8	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 04/2011
8	Ketone BodiesIBA 10/2017 - 04/2012
8	CarcinogensIBA 10/2017 - 06/2003
7	Anti-Bacterial Agents (Antibiotics)IBA 03/2020 - 08/2013
6	Messenger RNA (mRNA)IBA 01/2020 - 10/2010
6	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 01/2012
5	Estrogen ReceptorsIBA 11/2019 - 11/2006
4	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2021 - 09/2015
4	CaveolinsIBA 01/2021 - 06/2009
4	Azithromycin (Zithromax)FDA LinkGeneric 03/2020 - 03/2015
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 08/2011
4	P-2 (P 2)IBA 01/2020 - 09/2017
4	Biological ProductsIBA 01/2019 - 02/2010
4	Proliferating Cell Nuclear Antigen (PCNA)IBA 09/2017 - 01/2014
4	Transcription Factors (Transcription Factor)IBA 09/2015 - 06/2010
4	Cyclin D1IBA 01/2014 - 06/2003
4	AntibodiesIBA 12/2012 - 06/2009
4	Chloroquine (Aralen)FDA LinkGeneric 12/2012 - 06/2010
4	PoisonsIBA 11/2012 - 04/2011
4	Caveolin 3IBA 02/2010 - 01/2002
3	bedaquiline (R207910)IBA 01/2021 - 01/2016
3	Mitochondrial Proton-Translocating ATPases (Mitochondrial ATP Synthase)IBA 01/2021 - 01/2016
3	Phenobarbital (Luminal)FDA Link 11/2019 - 01/2006
3	SolutionsIBA 09/2017 - 09/2010
3	DNA (Deoxyribonucleic Acid)IBA 06/2015 - 11/2012
3	Therapeutic UsesIBA 03/2015 - 12/2011
3	Estrogen Receptor alphaIBA 05/2014 - 06/2006
3	Amino Acids FDA Link 04/2014 - 09/2010
3	LigandsIBA 02/2013 - 08/2012
3	CytokinesIBA 05/2012 - 06/2011
3	CatalaseIBA 08/2011 - 05/2011
3	DystrophinIBA 04/2010 - 10/2003
3	Membrane Proteins (Integral Membrane Proteins)IBA 02/2008 - 10/2006
2	Coloring Agents (Dyes)IBA 01/2021 - 10/2003
2	Interleukin-6 (Interleukin 6)IBA 03/2020 - 02/2013
2	CholesterolIBA 01/2020 - 01/2011
2	ERRalpha Estrogen-Related ReceptorIBA 01/2020 - 09/2015
2	Small Interfering RNA (siRNA)IBA 11/2019 - 06/2010
2	GTP-Binding Proteins (G-Protein)IBA 12/2017 - 12/2017
2	Paclitaxel (Taxol)FDA LinkGeneric 08/2017 - 10/2015
2	palbociclibIBA 02/2017 - 10/2012
2	Telomerase (Telomerase Reverse Transcriptase)IBA 02/2017 - 09/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2015 - 09/2010
2	XCT790IBA 09/2015 - 06/2015
2	InterferonsIBA 05/2015 - 11/2012
2	Methionine (L-Methionine)FDA Link 03/2015 - 03/2008
2	Antineoplastic Agents (Antineoplastics)IBA 05/2013 - 12/2012
2	Cysteine (L-Cysteine)FDA Link 01/2013 - 11/2012
2	LipidsIBA 12/2012 - 12/2011
2	Milk Proteins (Milk Protein)IBA 11/2012 - 02/2009
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 09/2012 - 12/2011
2	Sirolimus (Rapamycin)FDA Link 07/2012 - 11/2010
2	AmmoniaIBA 12/2011 - 07/2011

Therapy/Procedure

58	Therapeutics 01/2021 - 08/2008
9	Drug Therapy (Chemotherapy) 01/2021 - 07/2010
5	Precision Medicine 09/2017 - 04/2011
4	Lasers (Laser) 01/2019 - 06/2006
3	Radiotherapy 01/2013 - 07/2010
2	Chemoprevention 01/2013 - 07/2012